Jim,
The differences between the two 'ways' can be fairly large. But,
on the whole, I honestly doubt if you would 'see' any difference in
performance. Running balanced lines near 'stuff' isn't as big a
'problem' as most people think. If you can stay away from things,
fine. If not, then try to stay as far away as possible, and keep the
proximity of the balanced line to other things 'symetrical' (if that
makes sence), both conductors an equal distance from the other stuff.
'Doc

PS - If the idea is to try something different or new, have at it!