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"Dr. Barry L. Ornitz" wrote in news:qmxIl.84715
: .... While we have been talking about conventional electrical transmission lines, we can also analyze nerves as a transmission line. A nerve is essentially an electrical transmission line with chemical transducers on each end. When a receptor synapse detects a neurotransmitter, like serotonin or norepinephrin, it sends an electrical signal down the neuron. The neuron is the transmission line. It is essentially an ionic conductor covered with a fatty substance known as myelin. The result is a distributed resistance- capacitance line. In diabetics, the myelin sheath is partially destroyed and replaced with sorbitol, a sugar alcohol. In addition to being more conductive than myelin, sorbitol has a far higher dielectric constant. Viewing the neuron as a distributed RC line, we have both added shunt conductance and increased the capacitance. It is no wonder that nerve conduction velocity and amplitude both decrease resulting in such things as peripheral neuropathy, usually associated with diabetics. I contracted a disease when I was young, a disease that caused the body's T cells to attack the cells of the mylon sheath (in our terms, the dielectric that separates the =ve and -ve ionic material in the nerve's coaxial cable, effectively shorting the coax. During a week or two of onset of the disease, the doctors performed TDR like tests on nerves in my legs, placing a pair if needles each side of a motor nerve, at each end of the nerve, and pulsing the nerve from a signal generator. The sig gen fired a CRO with a camera and 100' roll film back. They took thousands of pics over the couple of weeks, measuring attenuation and velocity of propagation. Yes, I am aware that there are parallels. Owen |
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