Running ladder line the whole way is the least lossy
vs mixing ladder line with coax, choke, etc..

Often, but not always:

* Depending on the impedances, frequencies and lengths involved, the
loss in a coax section can be lower than in the equivalent length of
ladderline.
* Although there may be losses in a 1:1 current balun at the
ladderline/coax transition, don't forget that there will also be
losses in the tuner balun if ladderline is used all the way; if the
ubiquitous 4:1 tuner internal voltage balun is used, those losses
could be significant.

Steve G3TXQ